Biomedical Applications

Biomedical Applications

 

Mitarbeiter gesucht!

Mittelfristig möchten wir unser Team im Bereich der Biomedizinischen Mikrowellensensoren erweitern.

Deshalb sind wir auf der Suche nach Kollegen, die als Wissenschaftliche/r Mitarbeiter/in oder PostDoc unser Team verstärken.

Falls Sie Interesse haben an unsere Forschungsthemen in interdisziplinären Verbundprojekten mitzuarbeiten, kontaktieren Sie bitte:

Prof. Dr.-Ing. Rolf Jakoby

Dr.-Ing. Martin Schüßler

 

Biomedical Applications

The modern industry is interested in new universal adaptable and affordable sensor concepts in a wide range of applications which can be satisfied with microwave sensors. They are very versatile and can perform in different environments ranging from industrial, environmental to even biomedical applications. In many scenarios where dielectric properties of a certain object are of importance, microwave sensors can be employed. Their advantages lie in the facts that they can sense fast, continuous, non-invasively, non-destructive and in a contact-less way. Another reason is that most materials, organic and inorganic, have a specific frequency behavior which can provide information about their structure and function. Microwave sensor arrays are able to extract this information by retrieving these spectral signatures and give a spatial distribution of several materials under test (MUTs) simultaneously.

Fig. 1. Principle of operation for a planar metamaterial sensor. From the reflected and/or transmitted signal the information about the dielectric properties of the MUT and its distribution within the sensor array can be derived through the extraction of a capacitive profile.
Fig. 1. Principle of operation for a planar metamaterial sensor. From the reflected and/or transmitted signal the information about the dielectric properties of the MUT and its distribution within the sensor array can be derived through the extraction of a capacitive profile.

The research of the microwave engineering group in this field is focused on developing planar microwave sensors arrays for analysis and treatment in biomedical applications. All studied sensors have in common that they transduce the dielectric properties of materials under test in their direct vicinity into an electric signal. One of the main novelties of the developed sensor concepts is the array feature which allows making a simultaneous analysis of several materials under test with a single readout signal, or a relative characterization of one material with information about its spatial distribution. Additionally, the use of metamaterial structures as building elements for the development of the sensors gives them high flexibility in terms of geometry and operating frequency, enabling miniaturization and increased sensitivity by enhanced field interaction. The advantage of subwavelength image pixel resolution resulting from the discrete metamaterial unit cells was found as an additional feature.

The thorough examination of the sensor capabilities and proof-of-concept demonstration has been done in a wide range of application scenarios ranging from cytological studies in a microfluidic lab-on-chip environment to cancer detection and treatment in tissues. The purpose of the sensor that analyzes dielectric properties of cells is to monitor several separated cell samples simultaneously for changes in the concentration, the cell’s developing cycle stage or their vitality, for example, to monitor their specific reaction after drug exposure in a semi-automated way.

Fig. 2. Planar metamaterial sensor with integrated microfluidic channels for cytological screening.
Fig. 2. Planar metamaterial sensor with integrated microfluidic channels for cytological screening.

As for the medical environment the developed devices are particularly interesting because they offer the completely new possibility to operate the sensor in a dual mode: First, it is used as sensing device to screen the tissue for abnormalities. Secondly, for the first time, by changing the applied signals the device is used for treatment of cancer tissue by means of thermal ablation therapy. This procedure allows tumorous tissue to be eradicated in a highly focused way. Furthermore, the sensor is able to control the ablated area by operating again in sensing mode after the ablation procedure to ensure proper eradication of the cancer tissue with sufficient margins that will prevent its recurrence.

Fig. 3. Bioheat transfer mechanisms in organic tissue. Conduction and forced convection due to blood perfusion are highlighted.
Fig. 3. Bioheat transfer mechanisms in organic tissue. Conduction and forced convection due to blood perfusion are highlighted.
 
Fig. 4. Thermal measurements. a) Ablation with second ring pair of the SRR array, b) Ablation with third ring pair of the SRR array, c) Loaded SRR array.
Fig. 4. Thermal measurements. a) Ablation with second ring pair of the SRR array, b) Ablation with third ring pair of the SRR array, c) Loaded SRR array.

Most important publications

M. Puentes, M. Schüßler, and R. Jakoby. “Sensor Array Based on Split Ring Resonators for Analysis of Organic Tissues”. International Microwave Symposium. Baltimore, USA. June 2011.

M. Puentes, F.Bashir, M.Schüßler and R. Jakoby. “Dual Mode Microwave Tool for Dielectric Analysis and Thermal Ablation Treatment of Organic Tissue”, International Conference of the Engineering in Medicine and Biology Society. San Diego, USA. August 2012.

M. Schüßler, M. Puentes, D. Dubuc, K.Grenier and R. Jakoby. “Simultaneous Dielectric Monitoring of Micro fluidic Channels at Microwaves Utilizing a Metamaterial Transmission Line Structure”, International Conference of the Engineering in Medicine and Biology Society. San Diego, USA. August 2012.

M. Puentes, M. Maasch, M. Schüßler and R. Jakoby. “Frequency multiplexed2- dimensional sensor array based on split-ring resonators for organic tissue analysis”, IEEE Transactions on Microwave Theory and Techniques, Vol 60, Issue 6, pp: 1720 – 1727, June 2012.

M. Schüßler, C. Mandel, M. Puentes and R. Jakoby. “Metamaterial Inspired Microwave Sensors”, Microwave Magazine, March-April 2012.

List of all publications

Reimann, C. ; Puentes, M. ; Schüßler, M. ; Hübner, F. ; Bazrafshan, B. ; Vogl, T. J. ; Jakoby, R. :
Theranostic microwave applicator suitable for minimal invasive therapy of malignant tissue.
[Online-Edition: https://doi.org/10.1109/EMBC.2016.7590709]
In: 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).
[Konferenz- oder Workshop-Beitrag], (2016)

Reimann, C. ; Puentes, M. ; Schüßler, M. ; Jakoby, R. :
Design and realization of a microwave applicator for diagnosis and thermal ablation treatment of cancerous tissue.
[Online-Edition: https://doi.org/10.1109/GEMIC.2016.7461584]
In: 2016 German Microwave Conference (GeMiC).
[Konferenz- oder Workshop-Beitrag], (2016)

Reimann, Carolin ; Puentes, Margarita ; Maasch, Matthias ; Hübner, Frank ; Bazrafshan, Babak ; Vogl, Thomas J. ; Damm, Christian ; Jakoby, Rolf :
Planar Microwave Sensor for Theranostic Therapy of Organic Tissue Based on Oval Split Ring Resonators.
[Online-Edition: http://dx.doi.org/10.3390/s16091450]
In: Sensors, 16 (9)
[Artikel], (2016)

Schüßler, M. ; Puentes, M. ; Jakoby, R. ; Dubuc, D. ; Grenier, K. :
Microwaves for microfluidic biosensor arrays.
[Online-Edition: http://dx.doi.org/10.1109/EuMC.2015.7345893]
In: European Microwave Conference (EuMC).
[Konferenz- oder Workshop-Beitrag], (2015)

Puentes, M. ; Schüßler, M. ; Damm, C. ; Jakoby, R. :
Evolution of a microwave instrument for analysis and thermal ablation of organic tissue.
[Online-Edition: http://dx.doi.org/10.1109/EuMC.2014.6986425]
In: 44th European Microwave Conference (EuMC).
[Konferenz- oder Workshop-Beitrag], (2014)

Puentes, M. ; Maasch, M. ; Schüßler, M. ; Damm, C. ; Jakoby, R. :
Analysis of resonant particles in a coplanar microwave sensor array for thermal ablation of organic tissue.
In: Microwave Symposium (IMS), 2014 IEEE MTT-S International.
[Konferenz- oder Workshop-Beitrag], (2014)

Puentes Vargas, Margarita :
Planar Metamaterial Based Microwave Sensor Arrays for Biomedical Analysis and Treatment.
Springer , Berlin
[Dissertation], (2014)

Puentes, M. ; Bashir, F. ; Maasch, M. ; Schüßler, M. ; Jakoby, R. :
Planar Microwave Sensor for Thermal Ablation of Organic Tissue.
In: European Microwave Conference 2013, October 2013, Nuremberg, Germany.
[Konferenz- oder Workshop-Beitrag], (2013)

Puentes, M. ; Bashir, F. ; Schüßler, M. ; Jakoby, R. :
Dual Mode Microwave Tool for Dielectric Analysis and Thermal Ablation Treatment of Organic Tissue.
In: International Conference of the Engineering in Medicine and Biology Society, August 2012, San Diego, USA.
[Konferenz- oder Workshop-Beitrag], (2012)

Schüßler, M. ; Puentes, M. ; Dubuc, D. ; Grenier, K. ; Jakoby, R. :
Simultaneous Dielectric Monitoring of Micro fluidic Channels at Microwaves Utilizing a Metamaterial Transmission Line Structure.
In: International Conference of the Engineering in Medicine and Biology Society, August 2012, San Diego, USA.
[Konferenz- oder Workshop-Beitrag], (2012)

Puentes, M. ; Maasch, M. ; Schüßler, M. ; Jakoby, R. :
Frequency multiplexed 2-dimensional sensor array based on split-ring resonators for organic tissue analysis.
In: IEEE Transactions on Microwave Theory and Techniques, Vol 60 (Issue 6) 1720- 1727.
[Artikel], (2012)

Schüßler, M. ; Mandel, C. ; Puentes, M. ; Jakoby, R. :
Metamaterial Inspired Microwave Sensors.
In: IEEE Microwave Magazine, 13 (2) pp. 57-68.
[Artikel], (2012)

Puentes, M. ; Schüßler, M. ; Jakoby, R. :
2D Sensor Array based on Split Rings Resonators for Monitoring of Organic Tissue.
In: International Conference IEEE Sensors 2011, Oct. 2011, Limerick, Ireland.
[Konferenz- oder Workshop-Beitrag], (2011)

Schüßler, M. ; Puentes, M. ; Mandel, C. ; Jakoby, R. :
Capacitive Level Sensor for Layered Fillings in Tanks and Vessles based on Metamaterial Transmission Line.
In: International Conference IEEE Sensors 2011, Oct. 2011, Limerick, Ireland.
[Konferenz- oder Workshop-Beitrag], (2011)

Puentes, M. ; Schüßler, M. ; Jakoby, R. :
Sensor Array Based on Split Ring Resonators for Analysis of Organic Tissues.
In: International Microwave Symposium, June 2011, Baltimore, USA.
[Konferenz- oder Workshop-Beitrag], (2011)

Puentes, M. ; Weiss, C. ; Schussler, M. ; Jakoby, R. :
Sensor array based on split ring resonators for analysis of organic tissues.
In: Microwave Symposium Digest (MTT), 2011 IEEE MTT-S International.
[Konferenz- oder Workshop-Beitrag], (2011)

Schüßler, M. ; Puentes, M. ; Mandel, C. ; Jakoby, R. :
Capacitive Level Monitoring of Layered Fillings in Vessels using Composite Right/Left-Handed Transmission Lines.
In: IMS2011, International Microwave Symposium, June 2011, Baltimore, USA.
[Konferenz- oder Workshop-Beitrag], (2011)

Puentes, M. ; Schüßler, Martin ; Damm, C. ; Jakoby, Rolf :
Extraction of Capacitive Profiles with a Planar Metamaterial Sensor.
In: Applied Physics, 0947-8 pp. 1-5.
[Artikel], (2011)

Puentes, M. ; Schüßler, M. ; Penirschke, A. ; Damm, C. ; Jakoby, R. :
Metamaterials in Microwave Sensing Applications.
In: International Conference IEEE Sensors 2010, November 2010, Hawaii, USA.
[Konferenz- oder Workshop-Beitrag], (2010)

Penirschke, A. ; Puentes, M. ; Schüßler, M. ; Jakoby, R. :
Massendurchflusssensor für pneumatisch geförderte, pulverisierte Feststoffe in Förderleitungen, basierend auf linkshändigen Leitungsstrukturen.
In: Tm Technisches Messen, 77 (2) pp. 61-66.
[Artikel], (2010)

Damm, C. ; Schüßler, M. ; Puentes, M. ; Maune, H. ; Jakoby, R. :
Differential Transmission Line Sensor Based on Metamaterials.
In: META 2010, 2nd International Conference on Metamaterials, Photonic crystals and Plasmonics, February 2010, Cairo, Egypt.
[Konferenz- oder Workshop-Beitrag], (2010)

Mandel, C. ; Puentes, M. ; Schüßler, M. ; Jakoby, R. :
Concepts for Chipless Metamaterial-based Microwave RFID Transponders.
In: META 2010, 2nd International Conference on Metamaterials, Photonic crystals and Plasmonics, February 2010, Cairo, Egypt .
[Konferenz- oder Workshop-Beitrag], (2010)

Puentes, Margarita ; Schüßler, Martin ; Damm, Christian ; Penirschke, Andreas ; Jakoby, Rolf :
Capacity Sensor for Belt Conveyor Systems Based on Planar Metamaterials.
In: META 2010, 2nd International Conference on Metamaterials, Photonic crystals and Plasmonics, Cairo, Egypt.
[Konferenz- oder Workshop-Beitrag], (2010)

Puentes, M. ; Schüßler, M. ; Damm, C. ; Jakoby, R :
Extraction of Capacitive Profiles with CRLH Transmission Lines.
In: Frequenz, 5/6 pp. 74-78.
[Artikel], (2010)

Schüßler, M. ; Puentes, M. ; Mandel, C. ; Jakoby, Rolf :
Multi-Resonant Perturbation Method for Capacitive Sensing with Composite Right/Left-Handed Transmission Lines.
In: Proc. of Int. Microwave Symposium.
[Konferenz- oder Workshop-Beitrag], (2010)

Damm, C. ; Schüßler, M. ; Puentes, M. ; Maune, H. ; Maasch, M. ; Jakoby, Rolf :
Artificial Transmission Lines for High Sensitive Microwave Sensors.
In: Proceedings of IEEE Sensors. Christchurch, New Zealand
[Konferenz- oder Workshop-Beitrag], (2009)

Puentes, M. ; Stelling, B. ; Schüßler, M. ; Penirschke, A. ; Damm, C. ; Jakoby, R. :
Dual Mode Sensor for Belt Conveyor Systems Based on Planar Metamaterials.
In: International Conference IEEE Sensors 2009, October 2009, Christchurch, New Zealand.
[Konferenz- oder Workshop-Beitrag], (2009)

Puentes, M. ; Stelling, B. ; Schüßler, M. ; Penirschke, A. ; Jakoby, Rolf :
Sensor for Permittivity and Velocity Detection Based on Metamaterial Transmission Line Resonator.
In: 39th European Microwave Conference. Rome, Italy
[Konferenz- oder Workshop-Beitrag], (2009)

Penirschke, A. ; Puentes, M. ; Schüßler, M. ; Jakoby, Rolf :
Left-Handed Transmission Line Mass Flow Meter for Particulate Solids in Pipelines.
In: Sensor, 14th. International SENSOR Conference, Nuremberg, Germany.
[Konferenz- oder Workshop-Beitrag], (2009)

Penirschke, Andreas ; Puentes, Margarita ; Maune, Holger ; Schüßler, Martin ; Gaebler, Alexander ; Jakoby, Rolf :
Microwave mass flow meter for pneumatic conveyed particulate solids.
In: I2MTC, Singapore.
[Konferenz- oder Workshop-Beitrag], (2009)

Puentes, M. ; Schüßler, M. ; Penirschke, A. ; Jakoby, Rolf :
Microwave Mass Flow Meter for Industrial Applications based on a Left-handed Transmission Line.
In: German Microwave Conference. Munich, Germany
[Konferenz- oder Workshop-Beitrag], (2009)

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